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GLP-1 to Enable Reductions in Methadone Dose Size Does semaglutide or tirzepatide (given at first visit and ongoing) facilitate a reduction in dose or sustainable termination of methadone for patients currently on MMT for OUD

That means it is designed to act on three different hormone receptors involved in metabolism and appetite regulation: GIP, GLP-1, and glucagon

These changes reduce hunger signals throughout the day and help patients feel satisfied with smaller, more manageable portions